Vlog #16 In preparation for my climbing goal for later in the year, I reset my whole board to sharpen my best training tool. In this episode I get into why I did it and what the strategy was.
Vlog #15 I had mild/moderate depression for over 20 years. I tried many (non-drug) treatments but was unable to make any impact on it beyond managing the symptoms. Three years ago I made some dramatic changes to my diet for completely different reasons. An unexpected event that followed four weeks afterwards was that my depression completely resolved and has not returned. I will never know if the change caused the resolution. But as I discuss in this post, with reference to the evidence, it is at least plausible that it may have been causative. Nothing in this post is advice. I just want to share what I did. I should also urge anyone considering changes to their treatment regime for mental health issues, pharmacological or otherwise, to do so in consultation with their doctor.
The scientific references that accompany this post can be found below. I encourage interested viewers to read them in full rather than take them at face value.
References
1. LaChance, L. R. and D. Ramsey (2018). "Antidepressant foods: An evidence-based nutrient profiling system for depression." World journal of psychiatry 8(3): 97-104. https://www.ncbi.nlm.nih.gov/pubmed/30254980
2. Mattson, M. P., K. Moehl, N. Ghena, M. Schmaedick and A. Cheng (2018). "Intermittent metabolic switching, neuroplasticity and brain health." Nat Rev Neurosci 19(2): 63-80. https://www.ncbi.nlm.nih.gov/pubmed/29321682
3. Brietzke, E., R. B. Mansur, M. Subramaniapillai, V. Balanza-Martinez, M. Vinberg, A. Gonzalez-Pinto, J. D. Rosenblat, R. Ho and R. S. McIntyre (2018). "Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments." Neurosci Biobehav Rev 94: 11-16. https://www.ncbi.nlm.nih.gov/pubmed/30075165
4. Pinto, A., A. Bonucci, E. Maggi, M. Corsi and R. Businaro (2018). "Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Disease." Antioxidants (Basel) 7(5). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981249/
5. Gao, Y., M. Bielohuby, T. Fleming, G. F. Grabner, E. Foppen, W. Bernhard, M. Guzman-Ruiz, C. Layritz, B. Legutko, E. Zinser, C. Garcia-Caceres, R. M. Buijs, S. C. Woods, A. Kalsbeek, R. J. Seeley, P. P. Nawroth, M. Bidlingmaier, M. H. Tschop and C. X. Yi (2017). "Dietary sugars, not lipids, drive hypothalamic inflammation." Mol Metab 6(8): 897-908. https://www.ncbi.nlm.nih.gov/pubmed/28752053
6. Akhtar, S., A. Ahmed, M. A. Randhawa, S. Atukorala, N. Arlappa, T. Ismail and Z. Ali (2013). "Prevalence of vitamin A deficiency in South Asia: causes, outcomes, and possible remedies." Journal of health, population, and nutrition 31(4): 413-423. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905635/
7. Spiteller, G. and M. Afzal (2014). "The action of peroxyl radicals, powerful deleterious reagents, explains why neither cholesterol nor saturated fatty acids cause atherogenesis and age-related diseases." Chemistry 20(46): 14928-14945. https://www.ncbi.nlm.nih.gov/pubmed/25318456
8. Pepe, S., N. Tsuchiya, E. G. Lakatta and R. G. Hansford (1999). "PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH." Am J Physiol 276(1): H149-158. https://www.ncbi.nlm.nih.gov/pubmed/9887028
9. Treadway, M. T., J. A. Cooper and A. H. Miller (2019). “Can't or Won’t? Immunometabolic Constraints on Dopaminergic Drive." Trends in Cognitive Sciences 23(5): 435-448. https://www.ncbi.nlm.nih.gov/pubmed/30948204
10. Gerster, H. (1998). "Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?" Int J Vitam Nutr Res 68(3): 159-173. https://www.ncbi.nlm.nih.gov/pubmed/9637947
11. Hibbeln, J. R., K. Northstone, J. Evans and J. Golding (2018). "Vegetarian diets and depressive symptoms among men." J Affect Disord 225: 13-17. https://www.ncbi.nlm.nih.gov/pubmed/28777971
Further notes
In the video I discuss differences in plant/animal forms of vitamins and their precursors. This relates to the concept of bioavailability. For a discussion on this, see this paper:
Gregory, J. F., 3rd (2012). "Accounting for differences in the bioactivity and bioavailability of vitamers." Food & nutrition research 56: https://www.ncbi.nlm.nih.gov/pubmed/22489223
How I motivate myself to train. It's very simple. My books, training equipment are here: https://www.davemacleod.com/shop My Amazon page: https://www.amazon.co.uk/shop/davemacleod
Nevis Faces is a 6 part series of short films we made for the Nevis Landscape Partnership, exploring various characters who work and live around the Nevis area. Dr Cathy Mayne is an ecologist who specialises in mountain and upland environments.
Nevis Faces is a 6 part series of short films we made for the Nevis Landscape Partnership exploring various characters who work and live around the Nevis area. You can thank the enormous effort of Dougie Sinclair over the last 5 years for the huge improvement of the Ben Nevis Mountain path which is subject to significant erosion from over 160,000 visitors every year.
Nevis Faces is a 6 part series of short films we made for the Nevis Landscape Partnership which explores various characters who work and live around the Nevis area. Jamie Hageman is a self-taught mountain landscape painter and is suitably based in the West Highlands of Scotland where, surrounded by mountains, much of his painting inspiration comes from.
Nevis Faces is a 6 part series of short films we made for the Nevis Landscape Partnership which explores various characters who work and live around the Nevis area. Helen Rennard is an accomplished winter climber living in Fort William. We have made many first ascents together on Ben Nevis over the past ten years and Helen is one of the most solid climbing partners I know.
Nevis Faces is a 6 part series of short films we made for the Nevis Landscape Partnership, exploring various characters who work and live around the Nevis area. Dave 'Cubby' Cuthbertson is a mountaineer and landscape photographer. Watch his overnight stay on Tower Ridge to capture the sunrise over the North Face of Ben Nevis.
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